GR-127935 hydrochloride

CAS No. 148642-42-6

GR-127935 hydrochloride ( GR127935 )

Catalog No. M12050 CAS No. 148642-42-6

GR-127935 potent and selective 5-HT1B/1D receptor antagonist with pKi of 8.5 for both guinea pig 5-HT1D and rat 5-HT1B receptor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 284 Get Quote
50MG 1089 Get Quote
100MG 1647 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    GR-127935 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    GR-127935 potent and selective 5-HT1B/1D receptor antagonist with pKi of 8.5 for both guinea pig 5-HT1D and rat 5-HT1B receptor.
  • Description
    GR-127935 potent and selective 5-HT1B/1D receptor antagonist with pKi of 8.5 for both guinea pig 5-HT1D and rat 5-HT1B receptor; displays >100-fold selectivity over 5HT1A, 5-HT2A, 5-HT2C receptors and other receptor types; blocks porcine carotid vascular response to sumatriptan in vivo; orally bioavailable and centrally active.
  • Synonyms
    GR127935
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    5-HT Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    148642-42-6
  • Formula Weight
    534.06
  • Molecular Formula
    C29H31N5O3.HCl
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(C1=CC=C(C2=CC=C(C3=NOC(C)=N3)C=C2C)C=C1)NC4=CC=C(OC)C(N5CCN(C)CC5)=C4.[H]Cl
  • Chemical Name
    N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]benzamide hydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Clitherow JW, et al. J Med Chem. 1994 Jul 22;37(15):2253-7.
2. Knobelman DA, et al. J Pharmacol Exp Ther. 2001 Sep;298(3):1083-91.
3. De Vries P, et al. Br J Pharmacol. 1996 May;118(1):85-92.
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